EC Number   |
Reaction |
Reference |
|---|
   3.4.23.45 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
- |
- |
| 3.4.23.45 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
active site structure, substrate binding structure, tetrahedral transition state intermediate |
669871 |
| 3.4.23.45 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
cleavage at the beta-site but more effectively at a different site within A-beta |
684385 |
| 3.4.23.45 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
preferential cleavage of amyloid precursor protein downstream of the alpha-site of A-beta (after Phe19, theta-site), resulting N-terminal sequence of product is FAEDVGSN |
686629 |
| 3.4.23.45 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
preferential cleavage of the amyloid precursor protein between Phe690 and Phe691 or Phe691 and Ala692 |
683144 |
| 3.4.23.45 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
preferential cleavage within the A-beta region at Phe19 or Phe20 |
683469 |
