EC Number   |
Reaction |
Reference |
|---|
   3.2.2.27 | Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil |
- |
- |
| 3.2.2.27 | Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil |
a conserved asparagine residue acts as a ligand to the catalytic water molecule, and another water molecule acts as a barrier during substrate recognition, slide-in mechanism for initial damage recognition, catalytic reaction mechanism, overview |
-, 693621 |
| 3.2.2.27 | Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil |
active site structure and catalytic mechanism, overview |
-, 695028 |
| 3.2.2.27 | Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil |
catalytic reaction mechanism, the active side comprises the GEGPG motif, residues 40-44, the side-chain of Arg161 in family 4 TthUDG might play a role in binding AP-DNA after catalysis |
-, 693611 |
| 3.2.2.27 | Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil |
catalytic reaction mechanism, the catalytic residue is Asp93 |
692983 |
| 3.2.2.27 | Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil |
the active site catalytic residue is Asp88 |
-, 694419 |
| 3.2.2.27 | Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil |
the UDG active center contorts the uracil and deoxyribose while the phosphates 5' and 3' of the uridine are anchored by interactions with a proline-rich loop and a glycine-serine loop, UDG catalytic mechanism with channeling of DNA repair intermediates, overview |
694295 |
| 3.2.2.27 | Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil |
uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. UDGs form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA |
690240 |
