EC Number   |
Reaction |
Reference |
|---|
    2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
aryl sulfotransferase IV: Cys66 acts as a redox switch, but is not directly involved in the cataytic mechanism |
645672, 645688 |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
Asp86 is located at the active site in the intercalating mobile loop and responsible for substrate binding |
645684 |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
Cys70 is not essential for activity |
645660 |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
Glu146 determines the substrate specificity |
645668 |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
isozyme M-PST: ordered bisubstrate reaction mechanism |
645658 |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
isozyme P-PST: sequential ordered bisubstrate reaction mechanism |
645656 |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
mechanism |
-, 645688 |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
ping-pong mechanism |
645672 |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
random bi-bi mechanism catalytic mechanism of SULTs, many family members have distinct, but overlapping substrate specificities, the enzymes have a sequential catalytic mechanism that is susceptible to substrate inhibition |
676745 |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate |
structure modeling to determine Arg residues involved in the catalytic reaction: Arg257 is essential, located very close to 3'-phosphoadenylyl sulfate, the negative charge of Arg78 is not required, Arg130 is not critical |
645685 |
