EC Number   |
Reaction |
Reference |
|---|
    2.7.1.50 | ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole |
- |
- |
| 2.7.1.50 | ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole |
catalytic mechanism of phosphoryl transfer reaction and role of active site residues, e.g. R121 and C198, calculated on the basis of data on crystal structures of ribokinase-like kinases, transition state stabilization involves an oxyanion hole and a magnesium ion |
658936 |
| 2.7.1.50 | ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole |
SN2-like mechanism, with gamma-phosphate acting as an alcohol-activation base. Mg2+ ion 2, residues E126 and C198 play a major catalytic role, whereas Mg2+ ion 1 and C198 are responsible for product release |
693705 |
