2.7.1.33 | ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate |
active site structure, mechanism, pantothenate binding site structure, the reaction proceeds by a concerted mechanism that involves a dissociative transition state, although the negative charge neutralization of the gamma-phosphate by Arg243, Lys101, and Mg2+ coupled with hydrogen bonding of the C1 of pantothenate to Asp127 suggests different interpretations of the phosphoryl transfer mechanism of pantothenate kinase |
662251 |