2.5.1.86 | (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + trans,octacis-decaprenyl diphosphate |
mechanism: 1. the C5 unit of isopentenyl diphosphate adds to the a-end of the polyisoprene polymer, 2. in processive enzymes such as Rv2361c, the nascent chain (C15 to C45) moves to the polymer site displacing the diphosphate, 3. the empty isopentenyl diphosphate site is then reloaded and another C5 unit is added in an iterative fashion until the physiologically relevant chain length is generated |
-, 705121 |