EC Number |
Reaction |
Reference |
---|
2.5.1.19 | phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate |
- |
- |
2.5.1.19 | phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate |
binding of shikimate 3-phosphate leads to a saturable and stable conformational change in the isolated N-terminal domain |
638206 |
2.5.1.19 | phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate |
catalytic mechanism, tetrahedral reaction intermediate, active site structure, wild-type and mutant D313A |
659285 |
2.5.1.19 | phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate |
catalytic mechanism, tetrahedral reaction intermediate, catalytic cycle of the enzyme, overview |
658112 |
2.5.1.19 | phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate |
enolpyruvylshikimate 3-phosphate ketal is catalytically formed as side product upon enolpyruvyl activation through protonation by an intramolecular nucleophilic addition of O4 to C2 of the enolpyruvyl moiety |
678255 |
2.5.1.19 | phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate |
ordered substrate binding with 3-phosphoshikimate being bound first |
691936 |
2.5.1.19 | phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate |
proposed mechanism |
638176, 638177, 638201 |
2.5.1.19 | phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate |
via formation of a tetrahedral intermediate (TI) after which residue His385 is in a neutral form while residues Lys22, Lys340 and Lys411 are protonated, Asp313 mediates attack of the TI C4-OH group (as oxyanion, shikimate-3-phosphate moiety) at the TI C3-methyl group (phosphoenolpyruvate moiety), Lys22 serves as general acid catalyst for TI breakdown |
691197 |