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EC Number Reaction Commentary Reference
Show all pathways known for 2.3.3.14Display the word mapDisplay the reaction diagram Show all sequences 2.3.3.14acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA mechanism: 2-oxoglutarate first binds to the active site zinc via its alpha-carboxylate and 2-oxo groups, followed by acetyl-CoA. A general base then accepts a proton from the methyl of acetyl-CoA, and a general acid protonates the carbonyl of 2-oxoglutarate in the formation of homocitryl-CoA. The general acid then acts as a base in deprotonating Zn-OH2 in the hydrolysis of homocitryl-CoA to give homocitrate and CoA 672072
Show all pathways known for 2.3.3.14Display the word mapDisplay the reaction diagram Show all sequences 2.3.3.14acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA sequential mechanism -, 288192
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