2.3.2.27 | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine |
Ubr1 is an ubiquitin ligase, which is able to recignize N-end rule substrates. These substrates occur at two sites, type1 and type-2, specific for reecognition of basic N-terminal amino acid residues and responsible for recognition of bulky hydrophobic amino acid residues of proteins |
724995 |