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EC Number Reaction Commentary Reference
Show all pathways known for 2.3.1.247Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.247(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate - -
Show all pathways known for 2.3.1.247Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.247(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate the enzyme shows a catalytic reaction mechanism that proceeds through deprotonation of the 3-keto-5-aminohexanoate substrate, nucleophilic addition onto an incoming acetyl-CoA, intramolecular transfer of the CoA moiety, and final retro-Claisen reaction leading to acetoacetate and 3-aminobutyryl-CoA, structure-function analysis, docking study and molecular modeling, detailed overview. Absence of detection of any covalent acyl-enzyme intermediate 734167
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