EC Number   |
Reaction |
Reference |
|---|
    2.1.1.354 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 |
overall reaction |
- |
| 2.1.1.354 | S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4 |
(1a) |
- |
| 2.1.1.354 | S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 |
(1c) |
- |
| 2.1.1.354 | S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4 |
(1b) |
- |
| 2.1.1.354 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine |
enzyme is encoded on genes containing the SET-domain sequence, substrate specificity is connected to SET sequence |
485355 |
| 2.1.1.354 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine |
SET structure |
485355 |
