EC Number   |
Reaction |
Reference |
|---|
    1.14.14.1 | RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O |
a group of heme-thiolate proteins (P-450), acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins |
- |
| 1.14.14.1 | RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O |
active site structures and function-structure relationships of CYPS |
671725 |
| 1.14.14.1 | RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O |
catalytic reaction mechanism, structure-function relationship, CYP can oxidize non-nucleophilic substrates, CYP possesses genetic variability that may contribute to inter-individual variability observed for drug metabolism, the first step of CYP is the addition of substrate to the enzyme followed by electron transfer from the flavoprotein NADPH-CYP reductase to the substrate-bound CYP, then electrons flow to the FMN prosthetic group and then sequentially to the CYP to ultimately afford a reactive iron-oxo species, although other peroxy forms of the hemoprotein are proposed also to be oxidants involved in CYP-dependent metabolism |
671729 |
| 1.14.14.1 | RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O |
formation of a resonant network stabilizing the P450s catalytic site and allowing for interaction with substrates |
660414 |
| 1.14.14.1 | RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O |
formerly EC 1.14.1.1, EC 1.14.99.8 and EC 1.99.1.1 |
- |
| 1.14.14.1 | RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O |
reaction mechanism |
672721 |
| 1.14.14.1 | RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O |
reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups |
- |
| 1.14.14.1 | RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O |
some of the reactions attributed to EC 1.14.15.3 alkane 1-monooxygenase belong here |
- |
| 1.14.14.1 | RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O |
together with EC 1.6.2.4 NADPH-ferrihemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH2 |
- |
