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Results 1 - 5 of 5
EC Number Reaction Commentary Reference
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O - -
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O catalytic reaction mechanism, overview 765436
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O mechanism of kynurenine 3-monooxygenase-catalyzed hydroxylation reaction, quantum mechanical calculations on the hydroxylation reaction of the kynurenine pathway, which involves the oxidative half-reaction with low reaction rates, modeling by cluster method, detailed overview. The modeled mechanism involves four successive transformations: Somersault rearrangement (rate-determining step), hydride shift, keto-enol tautomerization, and the dehydration with facile barriers 765266
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O the mechanism of KMO is typical of class A FAH enzymes that exhibit ping-pong kinetics in which the aromatic substrate binds first, followed by NADPH and the reduction of FAD. The NADP+ formed must then dissociate prior to the addition of molecular oxygen and the commencement of the oxidative catalytic steps. The ping-pong mechanism thus facilitates the observation of the reductive and oxidative half-reactions in separate experiments by controlling the availability of the third substrate, dioxygen. The three phases observed during the oxidative half reaction are formation of the hydroperoxyflavin, hydroxylation and product release. Reaction via C4a-hydroperoxyflavin intermediate. The oxidative half-reaction is indeed the hydroxylation step and that the aromatic position C3 of L-Kyn experiences a sp2 to sp3 hybridization change for the transition state that occurs with electrophilic attack by the hydroperoxyflavin. A non-aromatic species is the immediate product of hydroxylation and that at least two solvent derived protons are in-flight during oxygen insertion to the substrate aromatic ring. A hydroxylation transition state in which two protons are shared between the proximal and distal oxygens of the C4a-hydroperoxide as the O-O bond is broken and as sp3 character is developed at the site of hydroxylation. Such a mechanism has the C4a-oxide and the diene-imine protonated simultaneously with the requisition of one these two protons from a water molecule. Proposed mechanisms of the oxidative half-reaction of KMO, detailed overview 764027
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O the mechanism of L-Kyn catalysis by KMO is composed of reductive and oxidative half reactions. The binding of the substrate induces the reduction of FAD by NADH or by NADPH 765242
Results 1 - 5 of 5