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EC Number Reaction Commentary Reference
Show all pathways known for 1.13.11.6Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.63-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde mechanism 439377
Show all pathways known for 1.13.11.6Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.63-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde reaction mechanism, overview 723950
Show all pathways known for 1.13.11.6Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.63-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde the 3HAO reaction is initiated by substrate binding, which induces closure of the active site. Oxygen then binds to the active-site iron. Transfer of an electron from the active-site iron to oxygen creates an oxygen radical, thereby facilitating the addition of both O atoms to 3-HANA and forming 2-amino-3-carboxymuconic 6-semialdehyde (ACMS), an active intermediate. ACMS then spontaneously cyclizes to form quinolinic acid 741516
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