EC Number   |
Reaction |
Reference |
|---|
    1.13.11.20 | L-cysteine + O2 = 3-sulfinoalanine |
catalytic mechanism of cysteine dioxygenase compared to the mechanism of sulfoxide synthase EgtB, EC 1.14.99.50, and its function of the active-site Tyr377 residue. In the sulfoxide syntase reaction, the conserved tyrosine residue reacts via proton-coupled electron transfer with the iron(III)-superoxo species and creates an iron(III)-hydroperoxo intermediate, thereby preventing the possible thiolate dioxygenation side reaction, detailed overview |
742755 |
| 1.13.11.20 | L-cysteine + O2 = 3-sulfinoalanine |
mechanism |
439544 |
| 1.13.11.20 | L-cysteine + O2 = 3-sulfinoalanine |
proposed catalytic cycle of CDO enzymes: the pentacoordinated resting state structure can convert to a hexacoordinated structure by binding of water. Upon binding of molecular oxygen the water molecule is displaced and an iron(III)-superoxo structure is formed. The terminal oxygen atom of the iron(III)-superoxo group attacks the sulfur of the cysteinate group to form a ring-structure, which can homogeneously split into a sulfoxide and iron(IV)-oxo species. The sulfoxide-bound complex rotates from sulfur-bound to oxygen-bound to the iron center. The latter transfers the oxygen atom from the iron(IV)-oxo group to substrate in a final step to form cysteine sulfinic acid product complex |
742264 |
| 1.13.11.20 | L-cysteine + O2 = 3-sulfinoalanine |
reaction mechanism |
743088 |
| 1.13.11.20 | L-cysteine + O2 = 3-sulfinoalanine |
reaction mechanism and structure-function analysis |
-, 743757 |
| 1.13.11.20 | L-cysteine + O2 = 3-sulfinoalanine |
reaction mechanism of cysteine oxygenation by CDO enzymes and reactivity of [TpMe,PhFe(CysOEt)] towards O2, detailed quantum mechanics/molecular mechanics calculations, overview |
742295 |
| 1.13.11.20 | L-cysteine + O2 = 3-sulfinoalanine |
reaction mechanism with internal electron transfer involving the ferric/ferrous enzyme forms, formation of a transient substrate-bound FeIII-superoxo species, overview |
724297 |
| 1.13.11.20 | L-cysteine + O2 = 3-sulfinoalanine |
Upon binding substrate, the structure of the iron site is pertubed but is still consistent with six O/N donor, indicating that cysteine may bind to the iron center, but is not bound via the sulfur atom. |
674569 |
