EC Number   |
Reaction |
Reference |
|---|
   1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
- |
- |
| 1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
bi bi ordered mechanism, kinetic analysis, overview |
687635 |
| 1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
enzyme isoforms bind substrate in different ways |
389547 |
| 1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
isozymes AKR1C1 and AKR1C2 are bifunctional enzymes also showing minor 20alpha-hydroxysteroid dehydrogenase activity, EC 1.1.1.149 |
654924 |
| 1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
isozymes also performs 17- and 20-ketosteroid reductase and 3alpha-, 17beta- and 20alpha-hydroxysteroid oxidase activities at varying rates |
656651 |
| 1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
ordered bi bi kinetic mechanism, catalytic residues are Y55 and H117 |
655215 |
| 1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
ordered bi bi kinetic reaction mechanism with nucleotide cofactor binding first |
654186 |
| 1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
rate-limiting step in the reaction is the release of NADH and proton. P185, T188 and the flexible substrate-binding loop are involved in binding with the nucleotide cofactor and with androsterone and are also involved in catalysis, catalytic mechanism, overview |
741274 |
| 1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
reaction mechanism |
654626 |
| 1.1.1.50 | a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ |
reaction mechanism: ordered bi bi with random substrate binding and ordered release of product, NADPH is released last, pro-R-hydrogen atom of NAD(P)H is transferred to carbonyl substrate |
- |
