EC Number   |
Reaction |
Reference |
|---|
    1.1.1.27 | (S)-lactate + NAD+ = pyruvate + NADH + H+ |
mechanism |
286471 |
| 1.1.1.27 | (S)-lactate + NAD+ = pyruvate + NADH + H+ |
reduction of pyruvate follows an Theorell-Chance mechanism |
286433 |
| 1.1.1.27 | (S)-lactate + NAD+ = pyruvate + NADH + H+ |
the enzyme LDHA shows an ordered bibi kinetic mechanism of nLDH with the coenzyme binding first |
-, 740458 |
| 1.1.1.27 | (S)-lactate + NAD+ = pyruvate + NADH + H+ |
the enzyme-NADH-pyruvate ternery complex undergoes a rate-limiting conformational change, in which the substrate loop closes to form a desolvated ternary complex in order to bring the catalytic residue Arg109 into the active site, the catalytic residues Arg109, Asp168, and His195 are highly conserved, catalyic mechanism, detailed overview |
711801 |
| 1.1.1.27 | (S)-lactate + NAD+ = pyruvate + NADH + H+ |
the NAD (H)-dependent L-LDH catalyzes the reduction of pyruvate by an ordered catalytic mechanism, catalytic cycle, overview |
684519 |
