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Results 1 - 9 of 9
EC Number
Reaction
Commentary
Reference
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
analysis of the reaction mechanism via an enzyme-bound intermediate beta-ketoacid pyridoxal-5'-phosphate aldimine, presence of multiple catalytic residues in the Escherichia coli enzyme
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
binding of pimeloyl-CoA causes a conformational change in the active site; binding study of L-alanine and D-alanine to the enzyme; Schiff base formation between D- or L-alanine and pyridoxal-5'-phophate in the active site
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
binding study of L-alanine and D-alanine to the enzyme; reaction mechanism
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
detailed catalytic reaction mechanism, overview
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
formation of an external intermediate beta-ketoacid pyridoxal-5'-phosphate aldimine, preference for L-alanine
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
reaction mechanism
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
reaction mechanism; reaction mechanism could be shared by all alpha-oxoamine synthases; reaction mechanism, formation of the pyridoxal-phosphate-stabilized carbanion by abstraction of the C2-H proton of the alanine-pyridoxal-phosphate aldimine, followed by acylation and decarboxylation
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
reaction mechanism; reaction mechanism, formation of the pyridoxal-phosphate-stabilized carbanion by abstraction of the C2-H proton of the alanine-pyridoxal-phosphate aldimine, followed by acylation and decarboxylation
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
via an AtbioF-PLP internal aldimine complex, i.e. a Schiff base formed between PLP and a Lys residue in the protein
Results 1 - 9 of 9