EC Number |
Reaction |
Reference |
---|
2.3.1.39 | malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] |
- |
- |
2.3.1.39 | malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] |
mechanism, formation of a malonyl-enzyme intermediate |
486863, 486864, 486881, 486882 |
2.3.1.39 | malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] |
isolation and characterization of an enzyme-intermediate |
486882, 486883 |
2.3.1.39 | malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] |
mechanism, kinetic studies |
486886, 486891 |
2.3.1.39 | malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] |
putative active site structure and involved catalytic residues |
661061 |
2.3.1.39 | malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] |
catalytic mechanism, [acyl-carrier protein] binding site, residues Phe200 and Met126 are involved |
663400 |
2.3.1.39 | malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] |
the catalytic malonyl transferase activity is intrinsic to an individual acyl carrier protein. An arginine/lysine in loop II and an arginine/glutamine in helix III are the catalytic residues for transferase function. The hydrogen bonding properties of these residues are indespensible for the transferase reaction |
705648 |
2.3.1.39 | malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] |
residues Arg113, Ser88 and His188 constitute the enzyme's catalytic triad, catalytic mechanism, detailed overview. Malonyl-CoA binds to MCAT, involving Ser88, Arg113, Met117 and Phe187. The second step forming an ACP-MCAT-malonyl intermediate is rate-limiting instead of the malonyl-CoA-MCAT intermediate formed in the first step. His87, Arg113 and Ser88 render different contributions for the two intermediates |
735606 |