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Results 1 - 10 of 15 > >>
EC Number
Reaction
Commentary
Reference
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
5-aminolevulinate synthase operates under the stereoelectronic control predicted by Dunathan’s hypothesis
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
covalent binding of pyridoxal 5'-phosphate and glycine to active site Lys131 is required for optimal activity; Tyr121, Asp279, Arg439, and Lys313 are involved in substrate and cofactor binding, mechanism, subunit localisation
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
cysteine in heme-regulatory motif; mechanism; pyridoxal 5'-phosphate binding site, sequence and function of glycine-rich motif
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
Lys313 acts as a general base during formation of the quinonoid reaction intermediates; mechanism
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism, aldimine linkage between pyridoxal 5’-phosphate and enzyme
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism; ordered bi-bi mechanism in which glycine binds first and 5-aminolevulinic acid dissociates last
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
proposed chemical mechanism of enzyme ALAS2 via (I) internal aldimine complex, (II) glycine-external aldimine, (III) quinonoid intermediate I, (IV) glycine-succinyl-CoA condensation intermediate, (V) 2-amino-3-ketoadipate intermediate, (VI) enol intermediate, (VII) quinonoid intermediate II, and (VIII) 5-aminolevulinate-external aldimine
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
proposed chemical mechanism of enzyme ALAS2. via (I) internal aldimine complex, (II) glycine-external aldimine, (III) quinonoid intermediate I, (IV) glycine–succinyl-CoA condensation intermediate, (V) 2-amino-3-ketoadipate intermediate, (VI) enol intermediate, (VII) quinonoid intermediate II, and (VIII) 5-aminolevulinate-external aldimine
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
pyridoxal 5'-phosphate binding site, sequence and function of glycine-rich motif; Tyr121, Asp279, Arg439, and Lys313 are involved in substrate and cofactor binding, mechanism, subunit localisation
Results 1 - 10 of 15 > >>