EC Number   |
Reaction  |
Reference |
|---|
    1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
addition of substrate and oxygen to the holoenzyme is formally random, holo-enzym in complex with substrate has a 3600-fold increase in oxygen reactivity |
657978 |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
dioxygen reactivity and the common decarboxylation half reaction, and the hydroxylation half reaction, mechanisms, detailed overview |
-, 741762 |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
dioxygen reactivity and the common decarboxylation half reaction, and the hydroxylation half reaction, mechanisms, inhibitor-bound crystal structure, PDB ID 1CJX, analysis, detailed overview |
741762 |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
direct involvement of the arene oxide intermediate to the reaction mechanism |
725432 |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
enzyme form 3: ordered bi bi mechanism where 4-hydroxyphenylpyruvate is added prior to oxygen and CO2 released before homogentisate |
395383 |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
evidence against participation of a quinol as a free intermediate |
395385 |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
homogentisate |
- |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
in plants this enzyme activity is involved in two distinct metabolic processes, the biosynthesis of prenylquinones and the catabolism of tyrosine |
395398 |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
mechanism of oxygen binding and activation, structural relationship to other dioxygenases |
658980 |
| 1.13.11.27 | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
mono-iso-ordered bi-bi mechanism with binding of 4-hydroxyphenylpyruvate before O2 and release of CO2 before homogentisate. A Theorell-Chance mechanism can not be excluded |
-, 395373 |
