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Results 1 - 5 of 5
EC Number Posttranslational Modification Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12glycoprotein - 668982
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12glycoprotein several glycosylation sites 652268
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12proteolytic modification cleavage by furin 651091
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12proteolytic modification recombinant enzyme is also processed in insect cells 651153
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12proteolytic modification synthesized as a zymogen, proADAMTS5. The propeptide excision mechanism is a major regulatory step. proADAMTS5 is processed by proprotein convertases, specifically furin and PC7, but not PC6B. proADAMTS5 processing occurs after Arg261. Cleaved ADAMTS5 propeptide and mature ADAMTS5 are found exclusively in the conditioned medium. Extracellular ADAMTS5 processing is supported by activation of proADAMTS5 added exogenously to HEK-293 cells stably expressing furin 708744
Results 1 - 5 of 5