EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.24.80 | glycoprotein |
glycosylation and palmitoylation of Cys 564 in the cytosolic tail |
679404 |
| 3.4.24.80 | phosphoprotein |
enzyme MT1-MMP is subject to protein kinase C (PKC)-mediated regulation via reversible phosphorylation, which alters intracellular trafficking and activity with thoracic aortic aneurysm (TAA). Phosphorylation of MT1-MMP mediates its activity through directing cellular localization |
754508 |
| 3.4.24.80 | phosphoprotein |
phosphorylated at Y573 and T567 |
720007 |
| 3.4.24.80 | proteolytic modification |
discoidin domain receptor 2 (DDR2) mediates collagen I-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts |
754158 |
| 3.4.24.80 | proteolytic modification |
furin processes MT1-MMP to its active form, inhibited by synthetic peptidyl chloromethyl ketones |
683300 |
| 3.4.24.80 | proteolytic modification |
guanosine 5'-O-[gamma-thio]triphosphate (GTPgammaS)-stimulated activation of MMP14 |
-, 754128 |
| 3.4.24.80 | proteolytic modification |
MMP-14 is activated from a pro-MMP-14 form |
709415 |
| 3.4.24.80 | proteolytic modification |
MMP14 requires removal of an N-terminal pro-domain sequence for its activation and presentation at the cell surface |
753773 |
| 3.4.24.80 | proteolytic modification |
MMP14 requires removal of an N-terminal pro-domain sequence for its activation and presentation at the cell surface. The pro-domain has two furin cleavage motifs, R89-R-P-R-C93 and R108-R-K-R-Y112 |
753773 |
| 3.4.24.80 | proteolytic modification |
MMPs zymogen activation is strictly controlled by a membrane-associated event strictly connecting MT-MMP and MMP functions |
710375 |
