EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.22.49 | more |
phosphorylation and potential autocleavage sites span the region of the last ARM repeats and the central unstructured region. Human separase has an N-terminal region spanned by 26 ARM repeats and separated from the two caspase-like domains, one of which is active, by the unstructured region |
718194 |
| 3.4.22.49 | phosphoprotein |
- |
682062, 731697 |
| 3.4.22.49 | phosphoprotein |
by phosphorylation of serine 1121 separase is negatively regulated |
682481 |
| 3.4.22.49 | phosphoprotein |
in vertebrate cells, separase is phosphorylated and inhibited before anaphase by a cyclin B/CDK1. This phosphorylation leads to an inhibitory binding of the cyclin B/CDK1 complex to separase |
718177 |
| 3.4.22.49 | phosphoprotein |
mitosis-specific phosphorylation of Ser-1126 decreases the solubility of separase by cyclin-dependent kinase 1-cyclin B1 |
732187 |
| 3.4.22.49 | phosphoprotein |
most of the budding yeast cohesin is cleaved in anaphase, and this cleavage is stimulated by phosphorylation of the Scc1 subunit by the Plk1 kinase |
718177 |
| 3.4.22.49 | phosphoprotein |
phosphorylation occurs under physiological conditions |
664553 |
| 3.4.22.49 | phosphoprotein |
phosphorylation on Ser1121, mechanism to inhibit activity prior to the onset of the anaphase. Inhibitory phosphorylation of separase is not required for meiosis. Critical role of separase phosphorylation in germ cell development as well as in early embryogenesis |
700165 |
| 3.4.22.49 | phosphoprotein |
phosphorylation sites span the region of the last ARM repeats and the central unstructured region |
718194 |
| 3.4.22.49 | phosphoprotein |
the enzyme is phosphorylated at serine residue 1126 |
732703 |
