EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.21.69 | glycoprotein |
- |
752736 |
| 3.4.21.69 | glycoprotein |
bovine protein C contains 14% carbohydrate, approximately 15 residues of hexose, 12 residues of hexosamine and 9 residues of sialic acid distributed in 3 carbohydrate chains, human protein C contains 23% carbohydrate, approximately 14 residues of galactose, 21 residues of mannose, 23 residues of glucosamine and 12 residues of sialic acid |
29601 |
| 3.4.21.69 | glycoprotein |
carbohydrate content: 14.9% |
29602 |
| 3.4.21.69 | glycoprotein |
different variants |
683670 |
| 3.4.21.69 | glycoprotein |
N-glycosylation of residues 97, 248, 313, and 329 |
683551, 683826 |
| 3.4.21.69 | glycoprotein |
N-linked glycan attachment site that is occupied by a complex sialyated glycan chain in about 70% of plasma protein C (termed protein C-alpha), but not in the remaining protein C pool, which is termed protein C-beta |
752736 |
| 3.4.21.69 | glycoprotein |
naturally occurring APC-beta plasma glycoform |
753066 |
| 3.4.21.69 | glycoprotein |
the enzyme is in naturally occurring APC-beta plasma glycoform, N-glycosidase PNGase F treatment of APC excises all N-linked glycans leading to a fourfold increased PAR1 proteolysis compared to untreated APC |
753066 |
| 3.4.21.69 | proteolytic modification |
in thrombotic stress, the protein C zymogen is converted to its active form by thrombin in complex with endothelial surface thrombomodulin |
683035 |
| 3.4.21.69 | proteolytic modification |
inactive plasma zymogen protein C is activated by proteolysis through the thrombin-thrmbomdulin complex on the vascular endothelial cell surface |
731565 |
