EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.17.2 | nitrosylation |
a post-translational DMPO-nitrone adduct formed with CPB1 in mice treated with a single bolus dose of lipopolysaccharide is detected |
708564 |
| 3.4.17.2 | nitrosylation |
LPS-induced septic shock produces tyrosine nitration in vivo which is due to the formation of peroxynitrite and is mediated by xanthine oxidase and nitric oxide synthase-3. Nitrosylation leads to the inactivation of the enzyme |
709356 |
| 3.4.17.2 | nitrosylation |
peroxynitrite-dependent tyrosine nitration leading to inactivation of the enzyme. At least 11 peptides with five sites of nitration on tyrosine residues are identified. These include Tyr92, Tyr210, Tyr277, Tyr248, and Tyr198. Of these, Tyr248 and Tyr198 are located in the catalytic site of CPB |
709356 |
| 3.4.17.2 | proteolytic modification |
40000 Da prepro form of the enzyme, 30000 Da mature enzyme form |
653363 |
| 3.4.17.2 | proteolytic modification |
cleavage and activation of the recombinant zymogen by trypsin |
669858 |
| 3.4.17.2 | proteolytic modification |
procarboxypeptidase B has a MW of 44500 Da, activation by bovine trypsin yields carboxypeptidase B |
36370 |
| 3.4.17.2 | proteolytic modification |
the enzyme contains a propeptide and a signal peptide |
668950 |
| 3.4.17.2 | proteolytic modification |
the enzyme is produced as secreted pro-enzyme |
668942 |
| 3.4.17.2 | proteolytic modification |
the enzyme is synthesized as zymogen, cleavage and activation in vitro by trypsin |
668815 |
| 3.4.17.2 | proteolytic modification |
the zymogen has a MW of 40000 Da |
36383 |
