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EC Number Posttranslational Modification Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.5.B1acetylation SAMHD1 is acetylated at residue K405 in vitro and in vivo by acetylatransferase arrest defective protein ARD1. Acetylated SAMHD1 wildtype proteins have enhanced dNTPase activity in vitro. SAMHD1 acetylation levels are strongest during the G1 phase 751773
Display the word mapDisplay the reaction diagram Show all sequences 3.1.5.B1phosphoprotein isoform ISF1 is phosphorylated at amino acids Ser49, Thr52, Ser55, Thr56, Thr310, and Thr634 with frequencies ranging from 21% to 56% 751090
Display the word mapDisplay the reaction diagram Show all sequences 3.1.5.B1phosphoprotein S-phase kinase CDK2-cyclin A phosphorylates SAMHD1 at residue Thr-592. Thr-592 phosphorylation occurs first at the G1/S border and is removed during mitotic exit. Thr-592 phosphorylation does not cause rapid protein degradation 750263
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