EC Number |
Posttranslational Modification |
Reference |
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1.5.1.6 | more |
FDH requires posttranslational modification to become a functional enzyme (4'-phosphopantetheine prosthetic group) |
687640 |
1.5.1.6 | more |
protein with conserved potential N-glycosylation sites, protein kinase phosphorylation sites, and N-myristoylation sites, post-translational modification may be important for the function |
392348 |
1.5.1.6 | more |
S375 is the putative site of enzyme phosphopantetheinylation |
724712 |
1.5.1.6 | phospholipoprotein |
the broad specificity human 4-phosphopantetheinyl transferase phosphopantetheinylates apo-FDH to holoenzyme and thus activates FDH catalysis. Silencing 4-phosphopantetheinyl transferase by small interfering RNA in A-549 cells prevents FDH modification |
712429 |
1.5.1.6 | proteolytic modification |
sequence contains a 22 amino acid N-terminal mitochondrial translocation signal |
712450 |