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EC Number Posttranslational Modification Commentary Reference
Show all pathways known for 1.14.19.17Display the word mapDisplay the reaction diagram Show all sequences 1.14.19.17lipoprotein myristoylation of Des1 increases the enzyme activity and alters its subcellular localization, targeting the enzyme from the endoplasmic reticulum to the mitochondrial outer membrane, where it causes an increase in ceramide levels that in turn leads to apoptosis 744686
Show all pathways known for 1.14.19.17Display the word mapDisplay the reaction diagram Show all sequences 1.14.19.17lipoprotein N-myristoylation targets DEGS1 from the endoplasmic reticulum to the mitochondrial outer membrane and increases its activity leading to an excess of ceramides and subsequent apoptosis in COS-7 cells, the effect is specific for myristic acid 744398
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