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Results 1 - 9 of 9
EC Number
Posttranslational Modification
Commentary
Reference
proteolytic modification
SPE B produced from group A Streptococcus (GAS) is released extracellularly to culture medium as a zymogen (proSPE B) with a molecular mass of 40 kDa. The conversion of proSPE B to the 28 kDa active mature SPE B (mSPE B) is achieved by autoproteolysis and exogenous proteases
proteolytic modification
Spe is expressed as a propeptide. Zinc blocks the maturation of the SpeB zymogen and thereby the proteolytic degradation of proteins by SpeB
proteolytic modification
SpeB is secreted as a 40000 Da proenzyme that is converted into a mature 28000 Da active proteinase by autocatalytic cleavage
proteolytic modification
the enzyme performs autolytic processing to the 28 kDa mature protein, the 12 kDa pro-sequence domain, residues 28-145, directs the folding of the mature enzyme, overview
proteolytic modification
the enzyme performs autolytic processing to the mature 28 kDa protein by removal of an about 117 amino-acid peptide from the N-terminus
side-chain modification
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side-chain modification
autocatalytic maturation of the zymogen proceeds through the sequential appearance of at least six intermediates, resulting from cleavage after Lys26, Asn41, Lys101, Ala112 and Lys118
side-chain modification
autocatalytic processing of the 40000 Da zymogen to the 28000 Da mature form
side-chain modification
complete removal of the 118 amino acids from the SCP zymogen results in formation of SCP
Results 1 - 9 of 9