EC Number   |
Application |
Reference |
|---|
    7.1.2.2 | drug development |
the enzyme is a target for development of specific inhibitors |
-, 710844 |
| 7.1.2.2 | medicine |
ATP hydrolysis by F1FO-ATPase is well preserved after hypoxia/reoxygenation as long as Mg2+ is available, indicating that function of the enzyme is largely intact, but ATP hydrolysis by F1FO-ATPase does not restore mitochondrial membrane potential as much as expected from the rate of ATP utilization, it is likely that uncoupling plays a major role in the mitochondrial dysfunction in proximal tubules during hypoxia/reoxygenation |
674212 |
| 7.1.2.2 | medicine |
F0F1 ATP synthase activity transiently increases during nonpreconditioned coronary reactive hyperemia, decreases 4 min after nonpreconditioned coronary reactive hyperemia and returns to control 2 min later, it is lower after ischemic preconditioning and does not change during and after preconditioned coronary reactive hyperemia, postischemic long-lasting inhibition of the enzyme activity may be a feature of the preconditioned heart |
671243 |
| 7.1.2.2 | medicine |
when hyperemia is induced before ischemic preconditioning, a steep increase in synthase capacity, followed by a deep decrease can be observed, hyperemia does not affect synthase capacity when applied after ischemic preconditioning, similar effects in vitro by treatment of heart biopsy samples with anoxia, which down-regulates, or high salt or high pH buffers, which up-regulates |
672313 |
| 7.1.2.2 | molecular biology |
F1FO-ATP synthase is a Na+-translocating ATPase used to generate an electrochemical gradient of Na+ that can drive other membrane-bound bioenergetic processes |
-, 669124 |
| 7.1.2.2 | more |
cleavage of the gamma subunit of the ATP synthase by trypsin prevents inhibition of ATPase activity by the sigma subunit, but only partially overcomes Mg2+-ADP inhibition during assay |
674396 |
| 7.1.2.2 | more |
formation of an active alpha3beta3EG hybrid complex by co-reconstitution of subunits alpha and beta of the F1-ATPase and of subunits E and G of Saccharomyces cerevisiae V-ATPase, the coupling subunit gamma inside the alpha3beta3 oligomer of F1 can be effectively replaced by subunit E of the V-ATPase, the E and gamma subunit are structurally similiar, but their genes do not show homology |
-, 674415 |
| 7.1.2.2 | more |
incorporation of F1F0 into soybean liposomes yields well-coupled and highly active proteoliposomes |
-, 672320 |
| 7.1.2.2 | more |
simple and inexpensive method to grow yeast to high density and purify the mitochondrial F1-ATPase quickly and efficiently |
-, 676946 |
| 7.1.2.2 | more |
site-specific spin-labeling of single cysteine mutations within mutant of subunit b of the ATP-synthase and employed electron spin resonance indicate tight binding interaction between b2 and F1, different binding interactions of b to F1 in the presence or absence of sigma, b preperations spin-labeled between amino acid position 101 and 114 are indicative of either two populations of b subunits with different packing interactions or to helical bending within this region |
-, 674416 |
