EC Number   |
Application |
Reference |
|---|
   5.6.1.6 | medicine |
analysis of patients with hypertriglyceridemia for mutations in the CFTR gene. 13 out of 126 patients carried a mutation in CFTR, all carrying I556V. Multivariate analysis indicates that triglycerides, CFTR mutation 470V, and TNF promoter 863A are independent risk markers for hypertriglyceridemia |
686150 |
| 5.6.1.6 | medicine |
CFTR is a phamacological target for activators and inhibitors, acivators are useful for phamacotherapy of cystic fibrosis, conversely, inhibitors are useful to treat secretory diarrhoea caused by enterotoxins |
673218 |
| 5.6.1.6 | medicine |
CFTR is involved in the pathogenesis of ovarian hyperstimulation syndrome by reproduction treatments, upon ovarian hyperstimulation enhanced CFTR expression and channel activity |
675997 |
| 5.6.1.6 | medicine |
novel mechanism for regulation of the vascular tone by cAMP-dependent CFTR chloride channels in vascular smooth muscle cells |
675622 |
| 5.6.1.6 | medicine |
role of CFTR in pathological cases, metabolic labelling of CFTR ex vivo in human tissue |
672380 |
| 5.6.1.6 | medicine |
SB-300, which targets the CFTR Cl- channel, is a low cost extract from Croton lechleri and may present a complementary and alternative medicine approach for the treatment of fluid loss in watery diarrhea |
675114 |
| 5.6.1.6 | more |
active scorpion venom of Leirus quinquestriatus hebraeus may be used as a tool to study the conformational changes that occur during CFTR gating |
672639 |
| 5.6.1.6 | more |
applicability of ten different antibodies under various fixation techniques for CFTR localization in fresh-brushed nasal epithelia cells collected from cystic fibrosis patients homozygous for F508del and control individuals |
675188 |
| 5.6.1.6 | more |
CFTR is a an ATP-dependent chloride channel, tightly regulated by phosphorylation, two distinct gating modes with one dependent on hydrolysis and the other requiring only stable ATP binding |
676761 |
| 5.6.1.6 | more |
coexpression of CFTR and murine or human epithelial Na+ channel in Xenopus laevis oocytes results in an 3fold increase in CFTR Cl- current, and a reduced amiloride-sensitive current, C-terminal 20 amino acid residues of alpha epithelial Na+ channel functional response to CFTR activation |
674413 |
