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Results 1 - 6 of 6
EC Number Application Commentary Reference
Show all pathways known for 5.1.99.1Display the word mapDisplay the reaction diagram Show all sequences 5.1.99.1analysis a simple direct assay for DL-methylmalonyl-coenzyme A racemase which is based on the fact that the proton on C-2 of methylmalonyl-CoA is replaced by a proton in the medium during racemization 2434
Show all pathways known for 5.1.99.1Display the word mapDisplay the reaction diagram Show all sequences 5.1.99.1medicine as model to study human methylmalonic aciduria, deletion of the mce gene results in a 80% decreased incorporation of propionate into macromolecules and induces an accumulation of methylmalonic acid 676032
Show all pathways known for 5.1.99.1Display the word mapDisplay the reaction diagram Show all sequences 5.1.99.1medicine point mutation in the methylmalonyl-CoA 2-epimerase gene (C139T) and an insertion polymorphism 41-160-161insT causes methylmalonic aciduria in patients, inhibition of the enzyme by siRNAs in HeLa cells reduces the synthesis of macromolecules 676026
Show all pathways known for 5.1.99.1Display the word mapDisplay the reaction diagram Show all sequences 5.1.99.1medicine point mutation in the methylmalonyl-CoA 2-epimerase gene (C139T) results in an early termination signal and causes methylmalonic aciduria in a patient 673947
Show all pathways known for 5.1.99.1Display the word mapDisplay the reaction diagram Show all sequences 5.1.99.1synthesis production of polyketides like myxothiazol requiring methylmalonyl-CoA as an extender unit 673023
Show all pathways known for 5.1.99.1Display the word mapDisplay the reaction diagram Show all sequences 5.1.99.1synthesis recombinant methylmalonyl-CoA epimerase enables biocatalytic epimerisation of C-2 methyl- and ethylmalonyl-CoA. When coupled with variant carboxymethylproline synthase CarB and crotonyl-CoA carboxylase reductase, the methylmalonyl-CoA epimerase forms part of a three-enzyme, one-pot procedure for the production of functionalised C-5 carboxyalkylprolines from crotonyl-CoA, carbon dioxide and L-glutamate semialdehyde/5-hydroxyproline/pyrroline-5-carboxylate 747542
Results 1 - 6 of 6