EC Number   |
Application |
Reference |
|---|
   4.3.3.2 | biotechnology |
modulating the substrate specificity of strictosidine synthase is a critical step toward indole alkaloid pathway engineering to yield nonnatural alkaloids |
679175 |
| 4.3.3.2 | biotechnology |
redesigning the substrate specificity of strictosidine synthase is an important step toward re-engineering the TIA pathway to produce products with novel or improved biological properties |
679162 |
| 4.3.3.2 | drug development |
cooverexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila |
746441 |
| 4.3.3.2 | drug development |
for modern industrial drug discovery, construction of alkaloid libraries with complex scaffolds and huge backbone diversity is of paramount importance. Strategies are reported that depend on single step strictosidine synthase-catalyzed reaction. Enzyme reengineering combined with chemical methodologies is straightforward to be accessed to produce a bunch of novel alkaloids with great scaffold diversity |
747618 |
| 4.3.3.2 | medicine |
anti-arrhythmic ajmaline agents |
663507 |
| 4.3.3.2 | medicine |
anti-arrhythmic heart disorders, ajmaline agents |
666582 |
| 4.3.3.2 | medicine |
anti-cancer and anti-hypertensive agents |
664326 |
| 4.3.3.2 | medicine |
anti-cancer, anti-hypertensive, anti-malaria and anti-arrhythmic ajmaline agents |
664183 |
| 4.3.3.2 | pharmacology |
cooverexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila |
746441 |
| 4.3.3.2 | synthesis |
decreased production of campothecin on subculturing due to a cross-species biosynthetic pathway is where the endophyte Fusarium solani utilizes indigenous geraniol 10-hydroxylase, secologanin synthase, and tryptophan decarboxylase to biosynthesize precursors. Fusarium solani requires host Campotheca acuminata strictosidine synthase in order to form strictosidine. Biosynthetic genes of campothecin in the seventh subculture generation of the endophyte reveal random and unpredictable nonsynonymous mutations. These random base substitutions lead to dysfunction at the amino acid level. The controls, Top1 gene and rDNA, remained intact over subculturing |
715978 |
