Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search Application

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 7 of 7
EC Number Application Commentary Reference
Show all pathways known for 3.5.2.9Display the word mapDisplay the reaction diagram Show all sequences 3.5.2.9medicine - 209393
Show all pathways known for 3.5.2.9Display the word mapDisplay the reaction diagram Show all sequences 3.5.2.9medicine 5-oxoprolinuria is primarily associated with inborn errors of the gamma-glutamyl cycle 688174
Show all pathways known for 3.5.2.9Display the word mapDisplay the reaction diagram Show all sequences 3.5.2.9medicine animal model for the human condition 5-oxoprolinuria, an inborn deficiency of renal 5-oxoprolinase activity -, 209386, 209390
Show all pathways known for 3.5.2.9Display the word mapDisplay the reaction diagram Show all sequences 3.5.2.9medicine clinical applications, substrate 5-oxo-L-proline sensitizes tumors to the alkylating agent melphalan 209391
Show all pathways known for 3.5.2.9Display the word mapDisplay the reaction diagram Show all sequences 3.5.2.9medicine occurrence of a futile cycle in patients with cystinosis. The enzyme gamma-glutamyl cysteine synthetase, in the absence of cysteine, forms 5-oxoproline instead of the normal substrate, gamma-glutamyl cysteine, and the 5-oxoproline is converted into glutamate by the ATP-dependant enzyme, 5-oxoprolinase. In cysteine-limiting conditions, glutamate is cycled back into glutamate via 5-oxoproline at the cost of two ATP molecules without production of glutathione and is the cause of the decreased levels of glutathione synthesis, as well as the ATP depletion observed in these cells 704751
Show all pathways known for 3.5.2.9Display the word mapDisplay the reaction diagram Show all sequences 3.5.2.9medicine potenial implications for carcinogenesis and cancer chemotherapy 209390
Show all pathways known for 3.5.2.9Display the word mapDisplay the reaction diagram Show all sequences 3.5.2.9medicine reduces normal tissue toxicity of anticancer agents 209389
Results 1 - 7 of 7