EC Number   |
Application |
Reference |
|---|
   3.4.99.B1 | medicine |
excision of RCE1 from skin carcinoma cell line retards the growth of cells significantly, and this effect was exaggerated by co-treatment with farnesyl-transferase inhibitor |
668781 |
| 3.4.99.B1 | medicine |
expression of Rce1 is significantly decreased in hepatocellular carcinoma compared with noncancerous tissues, while H-Ras expression is increased in the tumor. The expression of both is a close association with the differentiation and tumor-node-metastasis stage of the tumor. Rce1 is an independent prognostic indicator. Lower expression of Rce1 facilitates epithelial-mesenchymalctransition and promotes the invasion and metastasis of hepatocellular carcinoma |
754247 |
| 3.4.99.B1 | medicine |
Rce1 knockout mice have a dilated cardiomyopathy, by contrast, liver-specific Rce1 knockout mice appear healthy, endoproteolytic processing of CAAX proteins is essential for cardiac function but less important for the liver |
669285 |
| 3.4.99.B1 | more |
Rce1-mediated removal of of the last three amino acids from isoprenylated Rho GTPases is required for the proteolytic activity of Yersinia enterocolitca outer protein T in living cells |
668929 |
