EC Number   |
Application |
Reference |
|---|
   3.4.24.B11 | medicine |
ADAMTS1, ADAMTS5 and follicle stimulating hormone receptors are expressed 2.56, 2.10, and 2.66fold less in Sertoli cells of NOA patients, than those of obstructive azoospermia. After recombinant follicle stimulating hormone is added onto Sertoli cell cultures of patients with nonobstructive azoospermia, their expression does not increase significantly and does not reach to levels of control group. Expression of ADAMTS1 and ADAMTS5 are insignificantly 1.03 and 1.1fold higher in obstructive azoospermia group, respectively. In the nonobstructive azoospermia group, their expressions are 1.70 and 1.96fold lower, respectively, when compared with the fertile control |
755570 |
| 3.4.24.B11 | medicine |
expression of a majority of the investigated ADAMTS members ADAMTS-1, 4,5,6,8,9,10,13,17 on mRNA level is decreased in aneurysm compared to control aorta. ADAMTS-1 is one of the members that is reduced most. ADAMTS-1 is present predominantly in areas of smooth muscle cells and macrophages in aneurysmal aorta and higher expressed in abdominal aortic aneurysm compared to control aortas |
755146 |
| 3.4.24.B11 | medicine |
in men not on pravastatin, those homozygous for the 227Pro allele of ADAMTS1 have a nearly 2-fold increased risk of coronary heart disease events compared with noncarriers. In this high-risk group, treatment with pravastatin is highly efficacious, reducing the odds of fatal coronary disease or nonfatal myocardial infarction by approximately 75%, as compared with 25% in noncarriers or heterozygotes |
690661 |
| 3.4.24.B11 | medicine |
mean serum ADAMTS-1 level is increased in adolescents and younger-aged females with polycystic ovary syndrome (PCOS) compared to ovulatory controls. An elevated ADAMTS-1 level is positive predictive of the diagnosis of PCOS with the best cut-off value of 2.5 ng/ml. A positive predictive role of ADAMTS-1 on the development of cardiovascular disease risk and insulin resistance is found among all patients. Serum ADAMTS-1 and aggrecan levels are significantly and positively correlated with each other |
752600 |
| 3.4.24.B11 | medicine |
strong, diffuse staining is observed throughout myocardial tissue for ADAMTS1 both in individuals who died of myocardial infarction and a group who died of trauma. Among patients who died of myocardial infarction, no expression for ADAMTS1 is observed around fibrotic areas but slight staining in coagulative and necrotic zones |
754567 |
| 3.4.24.B11 | medicine |
syngeneic B16F1 melanoma model in wild type and ADAMTS1 knockout mice. Genetic deletion of ADAMTS1 in the host microenvironment results in a drastic decrease of tumor growth and metastasis. Reduced tumors in ADAMTS1 KO mice display a paradoxical increase in vascular density and vascular-related genes with an impaired vasculature, along with a minor infiltration of macrophages. ADAMTS1is involved in vascular sprouting, and melanoma xenografts show a relevant induction of its expression in stroma compartments |
754953 |
| 3.4.24.B11 | medicine |
tumor growth inhibitor |
667103, 667385, 667899, 668117, 668366, 669350, 669388, 670234, 670441, 670737 |
