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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.85medicine nelfinavir and its analogs inhibit castration-resistant prostate cancer proliferation by blocking regulated intramembrane proteolysis through suppression of site-2 protease cleavage activity. This leads to accumulation of precursors of sterol regulatory element-binding protein SREBP-1 and activating transcription factor ATF6, and development of insufficient reserves of their transcriptionally-active forms 733824
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.85synthesis in absence of cholesterol, SREBP double cleavage leads to activation of transcription of genes encoding multiple enzymes of the cholesterol biosynthetic pathway 644080
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