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Results 1 - 10 of 11 > >>
EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82degradation abrasion of cartilage aggrecan in rheumatoid arthritis and osteoarthritis 667796
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82degradation degradation of cartilage in late-stage Lyme arthritis -, 667360
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82degradation degradation of cartilage proteoglycan (aggrecan) in osteoarthritis and rheumatoid arthritis 669244
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82medicine ADAMTS-4 is a key enzyme in osteoarthritis 720093
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82medicine design and development for potent and selective inhibitors of ADAMTS-4 and ADAMTS-5, which will be required for chronic osteoarthritis therapy 709044
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82medicine full-length ADAMTS4 and its catalytically more active N-terminal 53 kDa autocatalytic fragment both promote B16 melanoma growth and angiogenesis in mice. Overexpression of its catalytically inactive E362A mutant or truncated fragments containing only the C-terminal ancillary domains suppresses melanoma growth and angiogenesis under similar conditions. The single thrombospondin-type 1 repeat domain is essential and sufficient for the antitumorigenic activity of the catalytically inactive ADAMTS4 isoforms. Suppression of tumor growth and angiogenesis in mice is accompanied by a significant increase in tumor cell apoptosis, whereas tumor cell proliferation is not affected 733990
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82medicine in synovial fluid of most orthopaedic patients ADAMTS-4 activity is undetectable. ADAMTS-4 ranges from 0 to 2.8 ng/mL in synovial fluid from patients with an injury, 0-4.1 ng/mL in osteoarthritic patients and 4.0-12.3 ng/mL in patients with large effusions 734830
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82medicine stop progression of cartilage degradation in osteoarthritis by prevention of aggrecan cleavage via inhibition of aggrecanase-1 696674
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82medicine the pattern of ADAMTS4 release observed is clearly different in various forms of ACS. ADAMTS4 shows a weak correlation with high-sensitivity C-reactive protein. However, no significant correlation is found between ADAMTS4 and troponin T in acute coronary syndromes patients 707655
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82medicine therapeutic target in osteoarthritis 679302
Results 1 - 10 of 11 > >>