EC Number |
Application |
Reference |
---|
3.4.24.68 | medicine |
causative agent of the disease tetanus |
652905 |
3.4.24.68 | medicine |
HuscFv antibodies specific for heavy chain can protect against tetanus neurotoxin by inhibiting binding of the enzyme to ganglioside GT1b |
754805 |
3.4.24.68 | medicine |
monoclonal antibody MAb 5C4 is the only anti-fragment C (heavy chain) antibody which is capable of blocking the binding of recombinant fragment C to GT1b gangliosides |
754911 |
3.4.24.68 | medicine |
sole causal agent of the pathological condition known as tetanus |
649097 |
3.4.24.68 | medicine |
sole cause of the devastating disease tetanus |
650578 |
3.4.24.68 | medicine |
the antibodies 2-7G, 2-2D, and S-4-7H can effectively inhibit the binding between the heavy chain fragment of the enzyme (TeNT-Hc) and differentiated PC-12 cells in vitro. Moreover, 2-7G inhibits TeNT-Hc binding to the receptor via carbohydrate-binding sites of the W pocket while 2-2D and S-4-7H inhibit binding of the R pocket. Although no single antibody completely protect mice from the toxin, they can prolong survival |
755610 |
3.4.24.68 | medicine |
treatment of T cells with recombinant carboxy-subdomain of the heavy chain results in development of Th1 lineage phenotype, which might lead to a specific and protective antibody mediated response against the enzyme |
753215 |
3.4.24.68 | medicine |
very powerful neurotoxin, agent responsible for all clinical symptoms of tetanus |
-, 653717 |