EC Number   |
Application |
Reference |
|---|
   3.4.22.59 | diagnostics |
excessive activation of caspase-6 is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment |
-, 698177 |
| 3.4.22.59 | drug development |
selective inhibitors of caspase-6 may have therapeutic potential for various neurodegenerative disorders |
718437 |
| 3.4.22.59 | drug development |
the enzyme is a target for therapeutic intervention in Alzheimer's and Huntington's diseases |
718301 |
| 3.4.22.59 | medicine |
caspase 6 expression remains elevated long after the occurrence of acute cell death during epileptogenesis and epilepsy, indicating that the enzyme has functions other than execution of programmed cell death in epileptogenic hippocampus |
670412 |
| 3.4.22.59 | medicine |
caspase-6 inhibition is a promising strategy to stop early stage neurodegenerative events |
755524 |
| 3.4.22.59 | medicine |
caspase-6 is active early in the pathogenesis of Alzheimer´s disease, the enzyme is strongly implicated in human neuronal degeneration and apoptosis, its inhibition may be an efficient treatment |
667134 |
| 3.4.22.59 | medicine |
caspase-6 is phosphorylated by AMP-activated protein kinase related kinase 5 at Ser257 in colorectal cancer cells, leading to inactivation of caspase-6 and resulting in resistance to cell death via cFLIPs protection and leading to resistance to the FAS ligand/Fas system |
670437 |
| 3.4.22.59 | medicine |
caspase-6 is upregulated in response to p53 overexpression, induction of caspase-6 expression lowers the cell death threshold in response to apoptotic signals that activate caspase-6, potential mechanism of lowering the death threshold, which could be important for chemosensitization |
670722 |
| 3.4.22.59 | medicine |
caspase-6 might be a key nod molecule to regulate immunological steady-state and be a therapeutic candidate for tumor immunotherapy |
754137 |
| 3.4.22.59 | medicine |
compared to caspase-3 there is a siginificant correlation between caspase-6 protein and necrosis and proliferation index of the analysed tumors |
680072 |
