EC Number   |
Application |
Reference |
|---|
   3.4.22.37 | biotechnology |
a naive camel nanobody library is constructed and phage display is used to select one nanobody toward RgpB with picomolar affinity. The nanobody is highly specific for RgpB given that it does not bind to the homologous gingipain HRgpA, indicating the presence of a binding epitope within the immunoglobulin-like domain of RgpB. RgpB can be used as a specific biomarker for Porphyromonas gingivalis infection |
717084 |
| 3.4.22.37 | diagnostics |
the enzyme activity is used for detection of periodontitis at an early stage of the disease |
668785 |
| 3.4.22.37 | drug development |
potential target for the development of an anti-periodontitis vaccination |
686776 |
| 3.4.22.37 | medicine |
development of potent, gingipain-specific inhibitors might be a helpful tool in a therapeutic strategy to prevent or treat periodontal disease |
699738 |
| 3.4.22.37 | medicine |
development of structure-based inhibitors for treatment of periodontal diseases |
-, 669799 |
| 3.4.22.37 | molecular biology |
enzyme is a convenient tool for protein chemistry due to its stability and activity under conditions of high detergent concentration used in protein solubilization and purification |
650451 |
| 3.4.22.37 | pharmacology |
enzyme structure is an excellent template for the rational design of drugs with a potential to cure and prevent periodontitis |
-, 650964 |
