EC Number   |
Application |
Reference |
|---|
   3.4.21.B25 | diagnostics |
expression of the enzyme correlates with prognosis in non-small cell lung cancer patients. Overall survival is significantly prolonged in PACE4 negative group when compared with PACE4 positive group (5-year survival rates, 23.1% vs. 54.5%, log-rank test), as is disease-free survival (5-year survival rates, 23.4% vs. 55.4%). Positive expression of PACE4 is an independent factor for non-small cell lung cancer patients and it might serve as a potential prognostic biomarker for patients with non-small cell lung cancer |
754509 |
| 3.4.21.B25 | medicine |
PACE4 overexpression results in enhanced susceptibility to carcinogenesis and tumor progression pointing to a new target for blocking tumor cell invasiveness, PACE4 enhances induced epidermal proliferation, activates matrix metalloproteinases in vivo, disrupts basement membrane structure, increases susceptibility to skin cancer and induces higher levels of matrix metalloproteinases and tumors of advanced malignant phenotype |
672901 |
| 3.4.21.B25 | medicine |
PACE4 represents a target for the development of osteoarthritis therapeutics |
690625 |
| 3.4.21.B25 | medicine |
PACE4 siRNA may exert antitumor activity through the mitochondrial pathway and is expected to be a promising therapeutic strategy for the treatment of pancreatic cancer |
754759 |
| 3.4.21.B25 | medicine |
the enzyme has an important role in prostate cancer cell proliferation and is a potential therapeutic target |
753401 |
| 3.4.21.B25 | medicine |
the enzyme is a validated target for prostate cancer |
753278 |
| 3.4.21.B25 | medicine |
the inhibition of the enzyme slows prostate cancer progression and is emerging as a promising therapeutic strategy |
753276 |
| 3.4.21.B25 | more |
maternal XPACE4 plays an important role in embryonic patterning by regulating the production of a subset of active mature TGFbeta proteins in specific sites, it is required for the endogenous mesoderm inducing activity of vegetal cells before gastrulation |
673252 |
| 3.4.21.B25 | more |
PACE4 contributes to prohormone processing under some circumstances |
673909 |
| 3.4.21.B25 | more |
PACE4 is crucial to normal adipocyte differentation |
673909 |
