EC Number   |
Application |
Reference |
|---|
   3.4.21.B24 | medicine |
abnormal processing of insulin growth factor-II by PC4 is involved in the pathophysiology of fetoplacental growth restriction |
676770 |
| 3.4.21.B24 | medicine |
manifold effects of proprotein convertases, influencing tumor cell proliferation, motility, adhesiveness, and invasiveness, should be exploited by further developing competitive or inhibitory therapeutic strategies that would be able to neutralize simultaneously the most salient cancer cell properties |
675917 |
| 3.4.21.B24 | medicine |
PC4 inhibitors may find potential therapeutic and clinical applications in male fertility |
694967 |
| 3.4.21.B24 | medicine |
PCSK4 appears to be a crucial enzyme for reproduction. Alterations of PCSK4 expression or activity could be the underlying cause of some unexplained cases of human infertility. Conversely, inactivation of this protease represents a potential strategy for non-hormonal contraception |
692581 |
| 3.4.21.B24 | more |
therapeutic targeting of PCSK4 for contraceptive purposes in man may not be associated with the endocrinological pitfalls of hormonal contraception. And PCSK4-based assays for sperm fertilizing ability is possible |
692581 |
