EC Number   |
Application |
Reference |
|---|
   3.4.21.93 | analysis |
highly specific and potent PC1 inhibitors proSAAS-(235-246) and proSAAS-(235-244) may be useful in development of an effective affinity procedure for the purification of PC1 |
652159 |
| 3.4.21.93 | drug development |
repression of proprotein convertase 1/3 by Pdcd4 may represent a novel mechanism for the function of Pdcd4 as a tumour suppressor |
696517 |
| 3.4.21.93 | medicine |
downregulation of prohormone convertase 1/3 by short-term morphine and upregulation by long-term morphine treatment may be a signal mediating the switch from drug use to drug abuse |
700473 |
| 3.4.21.93 | medicine |
extension of the clinical and molecular spectrum of human congenital PC1/3 deficiency |
687962 |
| 3.4.21.93 | medicine |
Pc1 N222D homozygous mice are obese and mimic humans with mutations in PC1. This mutation will be a valuable resource in understanding the role of prohormone processing in energy homeostasis |
-, 687032 |
| 3.4.21.93 | medicine |
prohormone convertase 1/3 activity is significantly lower in type 2 diabetic patients than in the control group. Decreased activity of prohormone convertase 1/3 rather than prohormone convertase 2 in pancreatic beta-cells is involved in the impaired proinsulin processing, resulting in elevated intact proinsulin levels in type 2 diabetic patients |
731716 |
| 3.4.21.93 | medicine |
role of prohormone convertase 1/3 in the transformation of corticotroph cell adenomas into Cushing's disease. Prohormone convertase 1/3 expression is negative or weak in the three patients in the initial phase of corticotroph cell adenoma, while a strong expression is observed in the majority of neoplastic cells in tissue specimens obtained from the same three patients at the time of recurrence as Cushing's disease |
753435 |
| 3.4.21.93 | medicine |
significant activation of PC1/3 in the alpha-cells of pancreatic islet is observed in mouse models of insulin resistance such as pregnant, obese, diabetic and prediabetic NOD mice. Data suggest a role of alpha-cells for beta-cell proliferation and further for the endocrine cell network within an islet |
717691 |
| 3.4.21.93 | medicine |
transplantation of PC1/3-expressing alpha-cells prevents streptozotocin-induced hyperglycemia by preserving beta-cell area and islet morphology, possibly via stimulating beta-cell replication. Expression of PC1/3 rather than PC2 in alpha-cells induces glucagon-like peptide 1 and glucagon-like peptide 2 production and converts the alpha-cell from a hyperglycemia-promoting cell to one that lowers blood glucose levels. Alteration of proglucagon processing in the alpha-cell may be therapeutically useful in the context of type 1 diabetes |
686303 |
| 3.4.21.93 | medicine |
UVB irradiation to the eye and stress loading increase the expression of prohormone convertase 1/3 and prohormone convertase 2 in the pituitary gland. The increase in expression of pituitary prohormone convertase 2 is greater in animals subjected to UVB eye irradiation than to stress, whereas no difference is seen between the two groups for the increase in PC1/3 |
731672 |
