EC Number   |
Application |
Reference |
|---|
   3.4.21.45 | medicine |
a single nucleotide polymorphism just 3' of complement factor I on chromosome 4 shows significant association with risk of advanced age-related macular degeneration |
697729 |
| 3.4.21.45 | medicine |
amyloid beta activates the complement system within drusen by blocking the function of factor I leading to a low-grade, chronic inflammation in subretinal tissues |
699340 |
| 3.4.21.45 | medicine |
association of complement factor I with atypical hemolytic uremic syndrome analyzed |
683883 |
| 3.4.21.45 | medicine |
case-control study of factor I gene involving 190 DNA samples from macular degeneration patients and 179 control samples genotypes six single nucleotide polymorphisms. Four single nucleotide polymorphisms are nominally significant in this initial analysis, and no single single nucleotide polymorphism maintains marginal significance after conservative Bonferroni correction for multiple testing. These four single nucleotide polymorphisms have very similar minor allele frequencies and are likely to be genetically hitchhiking with one another. Data implicate genomic variation in the region of the complement factor I gene with age-related macular disease susceptibility |
717566 |
| 3.4.21.45 | medicine |
expression of complement factor I in lung cancer cells analyzed |
683888 |
| 3.4.21.45 | medicine |
expression of complement factor I in non-small lung cancer cells analyzed |
683888 |
| 3.4.21.45 | medicine |
expression of complement factor I in non-small lung cancer cells and complement-dependent lysis analyzed |
683888 |
| 3.4.21.45 | medicine |
high enzyme expression in in breast cancer tumor cells is correlated with significantly shorter cancer-specific survival and recurrence-free survival |
753137 |
| 3.4.21.45 | medicine |
importance of screening patients with atypical hemolytic uremic syndrome for mutations in the CFI gene before renal transplantation, to avoid unsuccessful transplantation |
695445 |
| 3.4.21.45 | medicine |
presence of factor I decreases phagocytosis efficiency |
669758 |
