EC Number   |
Application |
Reference |
|---|
   3.4.21.38 | drug development |
a contact phase inhibitor of FXIIa is an effective and safe antithrombotic agent in vivo |
709320 |
| 3.4.21.38 | medicine |
activation of factor XIIa increase thrombin generation, which promotes thrombin-activated fibrinolysis inhibitor TAFIa-mediated attenuation of fibrinolysis |
670052 |
| 3.4.21.38 | medicine |
after transient middle cerebral artery occlusion, the volume of infarcted brain in enzyme-deficient or enzyme-inhibitor treated mice is substantially less than in control, without an increase in infarct-associated hemorrhage |
669671 |
| 3.4.21.38 | medicine |
decreased FXII activity may causally relate to reproductive failure |
695504 |
| 3.4.21.38 | medicine |
factor XII levels are lower and high molecular weight kininogen levels and the prevalence of factor XII, prekallikrein and high molecular weight kininogen deficiency higher in a population of patients with a history of venous thrombosis than in a population of healthy blood donors |
670943 |
| 3.4.21.38 | medicine |
folate-deficiency induced hyperhomocysteinemia reduces the functional activities of factors XII, X, and II. Folic acid supplementations restores |
669964 |
| 3.4.21.38 | medicine |
impaired factor XIIa-dependent activation of fibrinolysis as a key mechanism related to late-pregnancy complications in patients with the antiphospholipid syndrome |
667129 |
| 3.4.21.38 | medicine |
influence of blood coagulation factors on blood pressure analyzed, blood pressure and heart rate of bioassay rats studied after intravenous bolus of the activated beta-fragment of human coagulation factor XIIa |
683726 |
| 3.4.21.38 | medicine |
limited activation of factor XIIa is sufficient to promote plasma kallikrein activation, resulting in the conversion of high-molecular-weight kininogen and in bradykinin generation. Presence of platelets significantly promotes factor XIIa-initiated bradykinin formation and critically promotes factor XIIa-driven thrombin and fibrin formation |
667868 |
| 3.4.21.38 | medicine |
plasma level of factor XIIa is related to plasma levels of cholesterol and triglycerides. No association of plasma level of factor XIIa with risk of coronary events |
667353 |
