EC Number   |
Application |
Reference |
|---|
   3.4.14.1 | analysis |
application of substrate beta-(2-thienyl)Ala-beta-(7-methoxycoumarin-4-yl)Ala-Ser-Gly-Tyr(3-NO2) for detection of cathepsin C activity in various cell lysates, urine and bronchoalveolar lavage fluid samples |
752592 |
| 3.4.14.1 | analysis |
use in peptide sequence studies |
36126, 36127 |
| 3.4.14.1 | medicine |
assay for enzymic activity in urinary samples to diagnose for Papillon-Lefevre syndrome PLS, which is caused by mutations in both alleles of the cathepsin C. The absence of active CatC and its proform in the urine is a strong and reliable indicator for PLS and useful in the early diagnosis of PLS. In contrast, 100% of urine samples from control subjects of any age and gender contained measurable amounts of active CatC. Nonsense, frameshift and missense mutations all result in a total absence of CatC or CatC fragments in the urine of PLS patients |
753555 |
| 3.4.14.1 | medicine |
mast cell DPPI harms the septic host. DPPI is a novel potential therapeutic target for treatment of sepsis |
665827 |
| 3.4.14.1 | medicine |
mouse experimental autoimmune encephalomyelitis (EAE) model. In myelin oligodendrocyte glycoprotein EAE, CatC positive cells infiltrate the central nervous system at an early stage prior to any clinical signs, in comparison to wild-typemice. Cystatin F expression is not observed at this stage, but appears later within shadow plaques. CatC expression is found in chronic demyelinated lesions but is not associated with cystatin F expression, and CatCKD EAE mouse shows delayed demyelination |
754461 |
| 3.4.14.1 | medicine |
study of expression and activity levels of DPPI and its association with rheumatoid arthritis progress in a collagen-induced arthritis rat-model. Increased DPPI activities in synovial fluids, serum, and bone-marrow homogenates of collagen-induced arthritis rats are associated with rheumatoid arthritis severities progress. MMP2/9 expressions in synovial fluids and bone-marrow show different patterns. High DPPI activities are associated with granulocytes differentiations in-vivo in blood of collagen-induced arthritis rats. In-vitro cell models, DPPI up-regulates the proliferation of primary bone-marrow granulocytes of normal rats, but inhibits that of collagen-induced arthritis rats. DPPI up-regulates and presence of inhibitor Gly-Phe-CHN2 down-regulates mast cell intracellular DPPI and chymase activities. Inhibitor Gly-Phe-CHN2 also inhibits the LTB4-activated neutrophils and neutrophil-elastase activities |
753171 |
| 3.4.14.1 | nutrition |
muscle DPP I may be a key enzyme responsible for the generation of dipeptides in Jinhua ham processing |
666236 |
| 3.4.14.1 | synthesis |
specific and efficient method for complete removal of polyhistidine purification tags from the N-termini of target proteins |
36147 |
