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Results 1 - 3 of 3
EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.5.B1analysis high-throughput colorimetric assay for dNTP hydrolase activity, using Escherichia coli inorganic pyrophosphatase to convert triphosphate to 3 phosphates 751132
Display the word mapDisplay the reaction diagram Show all sequences 3.1.5.B1analysis high-throughput screen that directly measures SAMHD1 catalytic activity, utilizing bis(4-nitrophenyl) phosphate as the substrate and Mn2+ as the activating cation 749936
Display the word mapDisplay the reaction diagram Show all sequences 3.1.5.B1medicine in fibroblasts of patients with genetic mutations of deoxyguanosine kinase, SAMHD1 leads to manifestation of dNTP pool imbalance and DNA depletion. When SAMHD1 is silenced by siRNA transfection the composition of the mitochondrial dNTP pool approaches that of the controls, and DNA copy number increases 751048
Results 1 - 3 of 3