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Results 1 - 4 of 4
EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.54medicine effects of acute ethanol exposure to murine BV2 microglial cells. Ethanol downregulates microglial NAPE-PLD expression by activating cAMP/PKA and ERK1/2. Ethanol induces an increase in histone acetyltransferase activity which leads to higher levels of acetylation of histone H3 750480
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.54medicine the dorsomedial region of the ventromedial nucleus of the hypothalamusdisplays the necessary machinery for the endocannabinoid-mediated modulation of synaptic transmission of brain circuitries that regulate important hypothalamic functions such as feeding behaviors 729811
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.54nutrition delivering of N-acylphosphatidylethanolamines and N-acylethanolamides intestinally using gut bacteria synthesizing them. Unlike in wild-type mice, increasing intestinal levels of N-acylphosphatidylethanolamines using N-acylphosphatidylethanolamine-synthesizing bacteria in Nape-Pld-/- mice fails to reduce food intake and weight gain or alter gene expression. Increasing intestinal N-acylethanolamide levels in Nape-Pld-/- mice using N-acylethanolamide-synthesizing bacteria induces all of these effects. The N-acylethanolamide-synthesizing bacteria also markedly increase N-acylethanolamide levels and decrease inflammatory gene expression in omental adipose tissue 751274
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.54nutrition feeding of post-weaning male wild-type, NAPE-PLD-/+ and NAPE-PLD -/- mice isocaloric fat diets leads to increased levels in brain docosahexaenoic acid in NAPE-PLD-/+ and NAPE-PLD-/- mice compared to wild-type consuming fish oil. In NAPE-PLD-/- mice, brain docosahexaenoylethanolamide levels are higher after fish oil feeding. Liver and jejunum arachidonoylethanolamide, 1,2-arachidonoylglycerol and docosahexaenoylethanolamide levels reflect their corresponding fatty acid precursors. NAPE-PLD -/- mice have lower oleoylethanolamide levels in the jejunum and a leaner phenotype compared to wild-type mice 751374
Results 1 - 4 of 4